New Yorkers tell of hours stranded on snowy roads

FARMINGVILLE, N.Y. (AP) ? Stranded for hours on a snow-covered road, Priscilla Arena prayed, took out a sheet of loose-leaf paper and wrote what she thought might be her last words to her husband and children.

She told her 9 1/2-year-old daughter, Sophia, she was "picture-perfect beautiful." And she advised her 5 ?-year-old son, John: "Remember all the things that mommy taught you. Never say you hate someone you love. Take pride in the things you do, especially your family. ... Don't get angry at the small things; it's a waste of precious time and energy. Realize that all people are different, but most people are good. "

"My love will never die ? remember, always," she added.

Arena, who was rescued in an Army canvas truck after about 12 hours, was one of hundreds of drivers who spent a fearful, chilly night stuck on highways in a blizzard that plastered New York's Long Island with more than 30 inches of snow, its ferocity taking many by surprise despite warnings to stay off the roads.

Even plows were mired in the snow or blocked by stuck cars, so emergency workers had to resort to snowmobiles to try to reach motorists. Four-wheel-drive vehicles, tractor-trailers and a couple of ambulances could be seen stranded along the roadway and ramps of the Long Island Expressway. Stuck drivers peeked out from time to time, running their cars intermittently to warm up as they waited for help.

With many still stranded hours after the snow stopped, Gov. Andrew Cuomo urged other communities to send plows to help dig out in eastern Long Island, which took the state's hardest hit by far in the massive Northeast storm.

In Connecticut, where the storm dumped more than 3 feet of snow in some places, the National Guard rescued about 90 stranded motorists, taking a few to hospitals with hypothermia.

The scenes came almost exactly two years after a blizzard marooned at least 1,500 cars and buses on Chicago's iconic Lake Shore Drive, leaving hundreds of people shivering in their vehicles for as long as 12 hours and questioning why the city didn't close the crucial thoroughfare earlier.

Cuomo and other officials were similarly asked why they didn't act to shut down major highways in Long Island in advance of the storm, especially given the sprawling area's reputation for gridlock. The expressway is often called "the world's longest parking lot."

"The snow just swallowed them up. It came down so hard and so fast," explained Suffolk County Executive Steven Bellone.

"That's not an easy call," added Cuomo, who noted that people wanted to get home and that officials had warned them to take precautions because the worst of the snow could start by the evening rush hour. Flashing highway signs underscored the message ahead of time: "Heavy Snow Expected. Avoid PM Travel!"

"People need to act responsibly in these situations," Cuomo said.

But many workers didn't have the option of taking off early Friday, Arena noted. The 41-year-old sales account manager headed home from an optical supply business in Ronkonkoma around 4 p.m. She soon found her SUV stuck along a road in nearby Farmingville.

"Even though we would dig ourselves out and push forward, the snow kept piling, and therefore we all got stuck, all of us," she recalled later at Brookhaven Town Hall, where several dozen stranded motorists were taken after being rescued. Many others opted to stay with their cars.

Richard Ebbrecht left his Brooklyn chiropractic office around 3 p.m. for his home in Middle Island, about 60 miles away, calculating that he could make the drive home before the worst of the blizzard set in. He was wrong.

As the snow came rushing down faster than he'd foreseen, he got stuck six or seven times on the expressway and on other roads. Drivers began helping each other shovel and push, he said, but to no avail. He finally gave up and spent the night in his car on a local thoroughfare, only about two miles from his home.

"I could run my car and keep the heat on and listen to the radio a little bit," he said.

He walked home around at 8 a.m., leaving his car.

Late-shifters including Wayne Jingo had little choice but to risk it if they wanted to get home. By early afternoon, he'd been stuck in his pickup truck alongside the Long Island Expressway for nearly 12 hours.

He'd left his job around midnight as a postal worker at Kennedy Airport and headed home to Medford, about 50 miles east. He was at an exit in Ronkonkoma ? almost home ? around 1:45 a.m. when another driver came barreling at him westbound, the wrong way, he said. Jingo swerved to avoid the oncoming car, missed the exit and ended up stuck on the highway's grass shoulder.

He rocked the truck back and forth to try to free it, but it only sank down deeper into the snow and shredded one of his tires. He called 911. A police officer came by at 9:30 a.m. and said he would send a tow truck.

At 1 p.m. Saturday, Jingo was still waiting.

"I would have been fine if I didn't have to swerve," he said.

In Middle Island, a Wal-Mart remained unofficially open long past midnight to accommodate more than two dozen motorists who were stranded on nearby roads.

"We're here to mind the store, but we can't let people freeze out there," manager Jerry Greek told Newsday.

Officials weren't aware of any deaths among the stranded drivers, Cuomo said. Suffolk County police said no serious injuries had been reported among stuck motorists, but officers were still systematically checking stranded vehicles late Saturday afternoon.

Even cars that weren't stuck found the going on the expressway agonizingly slow ? especially for a 21-year-old mother-to-be who was trying to get to a hospital to deliver her baby Saturday morning. Her own mom was driving her, as the infant's father was snowbound elsewhere.

Suffolk County Police Officer Kevin Wustenhoff went to help and decided to drive the woman 15 miles to the hospital in his police SUV, rather than waiting for an ambulance.

As a father of three, "I was able to just kind of walk her through it ? breathing and just keeping her calm," he recalled later.

Delivery appeared imminent when they arrived, but the baby hadn't yet been born when Wustenhoff checked in late Saturday night.

While the expressway eventually opened Saturday, about 30 miles of the highway was to be closed again Sunday for snow removal.

Susan Cassara left her job at a Middle Island day care center around 6:30 p.m. Friday, after driving some of the children home because their parents couldn't get there to pick them up.

She got stuck on one road until about 2:30 a.m. Then a plow helped her get out ? but she got stuck again, she said. Finally, an Army National Guardsman got to her on a snowmobile after 4 a.m.

"It was so cool. Strapped on, held on and came all the way here" to the makeshift shelter at the Brookhaven Town Hall, she said. "Something for my bucket list."

___

Associated Press writers Mary Esch in Albany, N.Y.; Michael Melia in Hartford, Conn., and Jennifer Peltz and AP radio correspondent Julie Walker in New York contributed to this report.

Source: http://news.yahoo.com/yorkers-tell-hours-stranded-snowy-roads-203236121.html

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Telesur news channel gives Cubans glimpse of world

In this Feb. 1, 2013 photo, pictures of Cuban leader Fidel Castro and Cuba's President Raul Castro hang on the wall of a home as a television shows the Venezuelan channel Telesur in Havana, Cuba. Telesur, which is bankrolled primarily by Venezuela, has been broadcast live about 12 hours a day on the island's open airwaves since Jan. 20. Telesur's outlook may be sympathetic to Cuba's socialist model, but it's still a relatively unfiltered news source, and many say the decision to carry it here is as groundbreaking as other recent reforms, such as legalizing more private businesses or allowing greater travel freedom. Telesur was conceived as a force for regional integration and as a counterweight to Western channels such as CNN and the BBC. (AP Photo/Ismael Francisco, Cubadebate)

In this Feb. 1, 2013 photo, pictures of Cuban leader Fidel Castro and Cuba's President Raul Castro hang on the wall of a home as a television shows the Venezuelan channel Telesur in Havana, Cuba. Telesur, which is bankrolled primarily by Venezuela, has been broadcast live about 12 hours a day on the island's open airwaves since Jan. 20. Telesur's outlook may be sympathetic to Cuba's socialist model, but it's still a relatively unfiltered news source, and many say the decision to carry it here is as groundbreaking as other recent reforms, such as legalizing more private businesses or allowing greater travel freedom. Telesur was conceived as a force for regional integration and as a counterweight to Western channels such as CNN and the BBC. (AP Photo/Ismael Francisco, Cubadebate)

HAVANA (AP) ? There have been some strange sights on Cuban TV sets recently.

News-starved viewers watched an Ecuadorean opposition candidate liken the government of President Rafael Correa, one of Havana's staunchest allies, to a moonwalking Michael Jackson: He walks like he's moving ahead, but he's actually going backward.

On another day Cubans learned a quarter-billion of their fellow Latin Americans have access to the Internet ? something less than 10 percent of islanders can say themselves.

Cubans even watched a live broadcast of U.S. President Barack Obama's inaugural address.

Such images would be unremarkable in most countries, but they're a break from the stodgy, tightly scripted state-run television that has long been the only fare in Cuba, with its mind-numbing tributes to efficiency, constant diatribes against the U.S. economic embargo and remembrances of minor anniversaries from the early years of the 1959 revolution.

The change has come not from U.S.-funded TV Marti, which few Cubans can see, but via the left-leaning Latin American news channel Telesur, which is bankrolled primarily by Venezuela. Since Jan. 20, it has broadcast live about 12 hours a day in Cuba.

Telesur's outlook may be sympathetic to Cuba's socialist model, but it's still a relatively unfiltered news source, and many say the decision to carry it here is as groundbreaking as other recent reforms, such as legalizing more private businesses and allowing greater travel freedom.

"It's a window onto the world. It's a different way of seeing things," said Marcos Guizaldivar, a 41-year-old restaurant worker in Havana who said he was fascinated by Telesur and had all but tuned out Cuban state TV. "It would be great if they had it on 24 hours a day."

Guizaldivar and many others are captivated by Telesur's global newsgathering, fresh, real-time reports and slick production values, all novelties for an audience accustomed to low-budget weather graphics and word-for-word readings of lengthy essays by retired President Fidel Castro.

Even Telesur's critics welcome its arrival on the island.

"I think it is a positive step in Cuba, where all media are controlled by the Communist Party," said Carlos Lauria, senior Americas program director for the New York-based Committee to Project Journalists, a media advocacy group.

But he noted that Telesur is unlikely to report on internal issues that reflect poorly on Havana's government, such as Cuba's tiny dissident community or problems with the country's crumbling housing.

It's "limited, because there is no different or critical vision where dissent is expressed," Lauria said.

Telesur was conceived as a force for regional integration and as a counterweight to Western channels such as CNN and BBC. It began broadcasting in 2005 and receives majority funding from Venezuela, with the governments of Argentina, Bolivia, Cuba, Ecuador and Nicaragua contributing lesser shares.

All those countries are run by leaders considered part of the Latin American left, most notably Hugo Chavez of Venezuela, and critics of the channel point to examples of ideologically driven coverage, such as its pro-regime reports during the Libyan uprising against Moammar Gadhafi.

Arturo Lopez-Levy, a Cuba-born economist and University of Denver lecturer, said that no matter the editorial line, competition with private channels across the region means that Telesur doesn't have the luxury of ignoring major events.

A speech by a U.S. president, for example, was almost unheard of on Cuban TV in recent decades.

Telesur's programming gives islanders a close-up look at the more modern, messy, consumer-driven world outside.

One recent commercial urged viewers to use a smartphone app to follow Ecuador's elections ? something that's prohibitively expensive for most Cubans.

On a recent evening, Telesur covered a Venezuelan congressional session in which opposition lawmakers stridently defended themselves from critics across the aisle. That was an unusual image for Cuba, where parliament generally passes legislation unanimously, with discussion but without visible debate.

"The population will be exposed to a political model that distinguishes loyal opposition from treason ... that does not imply uncritical acceptance," Lopez-Levy said.

Telesur carries musical and historical programs, as well as documentaries with investigative journalism and reporters grilling their subjects. That, too, is a significant departure from the softball questions typical of Cuban news and the echo-chamber analysis of the nightly TV public affairs show.

And once baseball season begins, Cubans will watch highlights by Aroldis Chapman, Yoenis Cespedes and other Cuban stars whose names disappeared from official media after their defection, even as fans continue to pass news of their exploits in Major League Baseball by word of mouth.

"Telesur is something completely novel for us," said Felipa Martinez, a 68-year-old retired government office worker. "What's also valuable is that you can stay current on international events."

As with the recent law making it easier for Cubans to travel abroad, the government apparently is betting that familiarity with the outside world won't make people pushier about demanding political change or material goods.

"Putting Telesur (on air) is a challenge that the government has accepted," analyst and former Cuban diplomat Carlos Alzugaray told The Associated Press in Havana.

Telesur broadcasts every day in Cuba from 8 a.m. to 4 p.m. and again from 8 p.m. until it goes dark sometime after midnight. Cuba has carried the channel before, but only for two hours a day and with a delay that presumably let it avoid any objectionable content.

It's practically the only media available to most Cubans that's not filtered through the government. All newspapers and airwaves are state-controlled and carry the same dry content. Internet access is not widely available in Cuba, and foreign magazines and newspapers are nonexistent. U.S. government-funded Radio Marti and TV Marti broadcasts beamed at the island are mostly jammed by Cuba, and reception is spotty at best.

Some Cubans have had some increasing access to outside media in recent years. Hundreds of camouflaged, illegal dishes on rooftops capture satellite channels from Florida. Workers at hotels and foreign businesses can glimpse a cable service that offers foreign programming in Spanish, English, a handful of other European tongues and even Chinese.

Purveyors of pirated DVDs with the latest Hollywood movies and seasons of "CSI" are not only tolerated but licensed and regulated. Reruns of "Desperate Housewives" have become a mainstay on the open airwaves.

President Raul Castro has urged Cuban journalists to elevate the quality and creativity of their reporting, though there have been few examples of any newfound independence as yet.

Alzugaray, the former diplomat, said Telesur could provide an example for local reporters and their Communist Party-conscious bosses and help them shed the long-held mentality that it's risky to be too inquisitive.

"It's a different model of journalism, a model that many of us are demanding from Cuban journalism," he said. "It's a way of saying, 'Well, we can have revolutionary politics and still have discussion and diversity.'"

___

Andrea Rodriguez on Twitter: www.twitter.com/ARodriguezAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-10-CB-Cuba-Television/id-004877bf30cb439ba3b8154c20adedd8

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Iraq's Maliki: Assad could hold on for years

RIYADH (Reuters) - Syrian President Bashar al-Assad could survive two more years of revolt despite U.S. expectations of a more imminent fall, Iraqi Prime Minister Nuri al-Maliki was quoted as saying on Saturday.

Maliki, a Shi'ite Muslim, is seen as close to Assad's main ally Iran, but has been careful not to express support for either the Syrian leader, fighting a rebellion since early 2011, or the predominantly Sunni opposition.

In an interview in Cairo with the Saudi-owned, London-based Asharq al-Awsat, Maliki said U.S. President Barack Obama, Vice President Joe Biden and former secretary of state Hillary Clinton had told him Assad would fall "within two months".

He did not say when he had spoken to them.

Maliki said Assad would not fall "even after two years."

"I know Syria very well," he said, adding that Assad's minority Alawite sect would fight alongside other minority groups against rebels, which include Sunni Islamist militants.

Iraq has been mired in sectarian strife for 10 years and Baghdad fears the rise of a hardline Sunni government in Damascus could upset its own fragile security.

(Reporting By Angus McDowall; Editing by Matthew Tostevin)

Source: http://news.yahoo.com/iraqs-maliki-assad-could-hold-years-111027316.html

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Calcium-binding protein mutations found in heart rhythm disorders

Thursday, February 7, 2013

A team led by Vanderbilt University investigators has discovered two new genes ? both coding for the signaling protein calmodulin ? associated with severe early-onset disorders of heart rhythm. The findings, reported online Feb. 6 in the journal Circulation, expand the list of culprits that can cause sudden cardiac death and may point to new therapeutic approaches.

Nearly two decades of research have identified more than 25 genes in which mutations can increase risk for life-threatening cardiac arrhythmias, said Alfred George, Jr., M.D., chief of the Division of Genetic Medicine at Vanderbilt.

"Despite all this information, there are still cases that have no genetic diagnosis ? they don't have mutations in any of the known genes," he said.

Two such cases recently came to George's attention. They were both infants ? one in Italy, one in Chicago ? who suffered from early and repeated cardiac arrests requiring resuscitation, medications, and eventually, implantable defibrillators. Both infants had healthy parents with no symptoms and no family history of heart rhythm disorders, suggesting that the children had a de novo (spontaneous, non-inherited) mutation in a previously unknown arrhythmia susceptibility gene.

George and his colleagues recognized that these parent-child "trios" offered a unique opportunity to discover novel arrhythmia susceptibility genes.

At the time, Vanderbilt was building its resources in next-generation DNA sequencing, in part with funding from a National Institutes of Health instrumentation grant that George wrote. The researchers decided to use the new technology to scan the protein-coding regions across the genome (exome sequencing) in the parent-child trios. Using the trios allowed the investigators to zero in on the mutation causing the life-threatening disease.

"One of the biggest challenges in exome sequencing is sorting through the hundreds of thousands of gene variants to determine which one likely causes the disease," George explained. "In these cases, in which we suspected de novo mutations, we eliminated more than 90 percent of all the variants we found because they were transmitted from a parent."

Exome sequencing is a powerful approach and "is now a widely accepted strategy for discovering new gene mutations," George said.

In the infants, George and his colleagues discovered de novo mutations in two of the three genes coding for calmodulin, a calcium-binding protein essential for intracellular signaling in multiple tissues including heart.

The researchers also screened a group of patients with long QT syndrome (a condition that increases risk for fatal arrhythmias) who did not have any of the known long QT-associated genetic mutations. They discovered calmodulin mutations in two of these patients.

Walter Chazin, Ph.D., and Christopher Johnson, Ph.D., in the Vanderbilt Center for Structural Biology, investigated the impact of the mutations on calmodulin function. They found that all of the mutations impaired the ability of calmodulin to bind calcium.

"Calmodulin is known to interact with a whole host of proteins that we know are critically important for maintaining heart rhythm," George said. "So a dysfunctional calmodulin that can't bind calcium will almost certainly create an abnormal electrical effect in the heart."

The researchers are currently exploring how dysfunctional calmodulin affects electrical activity and causes arrhythmias. They also are working with pediatric cardiologists to identify additional parent-child trios (child with unexplained early-onset arrhythmia) for exome sequencing studies.

The hope, George said, is to fully understand the "pathways and networks of genes that cause early-onset severe arrhythmias" and to use that information to inspire new therapeutic approaches.

The genetic testing companies that screen for mutations in children with arrhythmias probably need to add the calmodulin genes to their list, George said.

George and his colleagues also plan to look for calmodulin gene mutations in cases of sudden infant death syndrome (SIDS) and late pregnancy stillbirth that have no clear cause of death.

"We know from previous studies that 10 percent of SIDS occurs because of a genetic arrhythmia predisposition," George said. "That percentage will likely increase when we screen new arrhythmia susceptibility genes, such as the calmodulin genes, for mutations."

The current study is the first published exome study using next-generation sequencing instrumentation in the VANTAGE (VANderbilt Technologies for Advanced Genomics) shared resource. It will not be the last, George said.

VANTAGE has now processed "several hundred exome sequencing samples," said Travis Clark, Ph.D., who was recruited from the biotechnology industry to lead VANTAGE's sequencing efforts.

"We have built up impressive genomics facilities at Vanderbilt," Clark added.

###

Vanderbilt University Medical Center: http://www.mc.vanderbilt.edu/npa

Thanks to Vanderbilt University Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126677/Calcium_binding_protein_mutations_found_in_heart_rhythm_disorders

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National Barbecue News: Texas Pitmaster John ... - Grilling with Rich

Today?s national barbecue news bite, we are going to be focusing on this interesting story coming out out of Austin, Texas. It looks like world famous pitmaster and restaurant owner John Mueller is retuning with a brand new barbecue joint: John Mueller Meat Co.

I think that this place will quickly become a must go to place in Austin!

by: Tom Thornton
February 5, 2013 via http://austinist.com

In October 2012, a family business dispute between?John Mueller?and his sister left the legendary pitmaster without a place to cook in Austin. After the departure, the South 1st trailer formerly known as?JMueller BBQ?was renamed?La Barbecue?to reflect the change in the kitchen. Since then, John?s next project has remained a mystery ? until now. On February 20, Mueller will open?John Mueller Meat Co.?at 2500 East 6th Street, where he?ll share an address with?Kellee?s Place. Kellee?s will allow Mueller patrons to bring in their BBQ if they?d like a beer with their meal. There will also be picnic-style seating outside.?The trailer will operate Tuesday through Saturday from 10:30am until sold out.

Mueller?s menu will initially look a lot like his creations at JMueller: brisket, beef ribs, sausage, pork ribs, pork shoulder, and turkey will round out the proteins, while sides will include pinto beans, baked squash, and potato salad. One notable change from Mueller?s previous outing: John Mueller Meat Co. will also serve as a limitedbutcher shop?and?grocery, selling to-go seasoned meats, sausages, relishes, and sauces.

In a winking nod to Mueller?s notorious reputation as a rabble rouser, a press release announcing the venture promises that ?meat fans can still expect to encounter Mueller?s trademark crotchety brand of customer service?some things never change.? For more information, follow?@JSM_meat?on Twitter or visit their new?Facebook page.

Category: BBQ News, Latest News

Source: http://www.grillingwithrich.com/national-barbecue-news-bite-texas-pitmaster-john-mueller-returns

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Kristen Wiig Joins 'Anchorman' Sequel

'Bridesmaids' comedian signs on as possible love interest for Steve Carell, according to reports.
By Josh Wigler

Kristen Wiig
Photo: Chris Weeks/ Getty Images

Source: http://www.mtv.com/news/articles/1701358/kristen-wiig-anchorman-sequel.jhtml

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Family Tree Tuesday ? Oliver Ames

Oliver Ames

Oliver Ames was the 35th Governor of Massachusetts during 1887-1890 and a financier. Prior to being governor he was lieutenant-governor of Massachusetts from 1882-1886. Ames had entered public life avowedly to vindicate his father?s memory.

Ames was born on February 4, 1831 in North Easton, Massachusetts to Oakes Ames and Eveline Gilmore. Oakes Ames was an American manufacturer, capitalist, and member of the U.S. House of Representatives from Massachusetts. As a congressman, he is credited by many historians as being the single most important influence in the building of the Union Pacific portion of the transcontinental railroad. He is also noted for the subsequent scandal that alleged the improper sale of stock of the railroad?s construction company.

Oakes Ames

Oakes Ames?was the son of Oliver Ames, Sr. who was a blacksmith that had built a business of making shovels and was nicknamed ?King of Spades?. Ames eventually became a partner in the business and established the firm Oliver Ames & Sons with his brother Oliver Ames, Jr. Ames made a large fortune during the Civil War. Through his influence, Ames obtained contracts for his family firm in the construction of the Union Pacific and staked nearly all the family?s holdings as capitalization for the project. The contracts were later transferred to the Credit Mobilier Company of America after Ames ousted its founder Thomas Durant. His brother Oliver, Jr. (1807-1877) was appointed president of the Union Pacific in 1866. It was disclosed in 1872 that Oakes Ames sold shares in Credit Mobilier to fellow congressmen at a price greatly below the market value of the stock which became a public scandal. In 1873, the House passed a resolution formally censuring Ames, detractors referred to him as ?Hoax Ames?. ?As his father?s heir, Oliver Ames, spent several years in paying off the obligations of millions of dollars incurred by the Union Pacific Railroad and other undertakings.?On the 14th anniversary of the completion of the railroad in 1883, the state legislature of Massachusetts passed a resolution exonerating Ames.

Oakes Ames (1874-1950) was the son of Oliver Ames (1831-1895), he was an American botanist specializing in orchids. He spent his entire professional career at Harvard and was elected a Fellow of the American Academy of Arts and Sciences in 1911. The Orchidaceae were little-known before Ames? study and classification. With his wife, Blanche Ames they made expeditions to create scientifically accurate drawings of the plants they cataloged. Their work was published in the seven-volume Orchidicae: Illustrations and Studies of the Family Orchidicae. They also developed the Ames Charts, illustrating the phylogenetic relationships of the major useful plants, which are still used. His estate is now the Borderland State Park in Massachusetts.

George Plimpton

American journalist, writer, editor, and actor, George Plimpton was Oakes Ames? grandson. Plimpton is widely known for his sports writing and for helping to found The Paris Review. He has appeared in a number of feature films as an extra and in cameo appearances. At Harvard, he was a classmate and close personal friend of Robert Kennedy. Plimpton, along with former decathlete Rafer Johnson, was credited with helping wrestle Sirhan Sirhan to the ground when Kennedy was assassinated at the former Ambassador Hotel in Los Angeles.

Check out Oliver Ames? family tree and see how you maybe related!

Source: http://www.geni.com/blog/family-tree-tuesday-oliver-ames-379198.html

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